Questions, answered honestly.

You pick a program, complete a secure clinical intake, and a licensed clinician reviews your health history and goals. If a medication is appropriate, it is prepared by an independent licensed pharmacy and shipped to you discreetly. Check-ins continue for as long as you are in the program. A clinician makes every clinical decision.

The fit check takes about two minutes and the clinical intake usually takes ten to fifteen. Clinician review timing depends on your state and whether a video visit is required. If you are prescribed, medication ships from the pharmacy after review.

No. Intake, clinician review, labs where indicated and ongoing messaging are all handled through secure, HIPAA-compliant telehealth. Some services and some states require a synchronous video visit, and your clinician will tell you if yours does.

Currently offering services in all 50 states plus Washington D.C. Some services may not be available in all 50 states or Washington D.C. Subject to change.

Use the My Portal link in the navigation. Your username is the email address you signed up with. You create your password after your first payment, and the portal is where you find your intake, messages, visits and labs.

Compounded medications are prepared by a licensed pharmacy for one individual patient, most often under the 503A pathway, against a clinician's prescription. They are lawful and widely used. They are not FDA-approved, which means the FDA has not reviewed that specific compounded product for safety, effectiveness or quality. We state this everywhere it is relevant rather than burying it.

The only way to know is a clinician review. Our fit check is a starting point and not a diagnosis. Eligibility depends on your full health history, your current medications and, for some programs, lab results. Not everyone qualifies, and we would rather tell you that early.

Anyone under 18, anyone seeking unsupervised or non-clinical use of prescription medication, and anyone whose history makes these medications inappropriate. Each program page lists its own contraindications, and a clinician screens for all of them during intake.

Yes. Protected health information is handled under HIPAA through our clinical infrastructure partner, OpenLoop. We do not sell your personal information. See our Privacy Policy and OpenLoop's Notice of Privacy Practices.

Contact your clinician through the portal first. For anything severe, call 911. You may also report adverse events directly to the FDA through MedWatch. Our Medication Safety Information page has the full detail.

It depends on the program. Longevity starts at $145 per 4 weeks, Microdosing at $179 per 4 weeks, Female Menopause - HRT at $237 per 12 weeks, and Medical Weight Loss at $249 per 4 weeks. Every price covers clinician review, medication if prescribed, base labs where indicated, shipping and ongoing support. No membership fee and no consult fee.

Yes, within a given option. Your price does not climb because your dose does, which means the clinical decision is never driven by what the next tier would cost you.

You can cancel any time. On refunds, the policy is specific: a full refund if you cancel within the first 72 hours of your subscription term and have not yet received services, and a refund if a clinician disqualifies you for a medical reason. For monthly subscriptions, no refund is issued for the month in which you cancel or for prior months. Federal law also prohibits returning dispensed prescription medication. The full terms are in our Cancellation & Refund Policy.

Email support@puremuze.com at least 72 hours before your next billing date, or cancel in your patient portal. You keep access through the end of the current billing cycle.

Yes. Eligible prescriptions ship in discreet packaging directly to your door, with nothing on the outside identifying the contents or the program.

Adults 18 and over who meet clinical criteria may qualify, though a prescription can never be guaranteed. Clinicians generally consider patients with a BMI over 25, or patients seeking maintenance therapy with a BMI over 22 who have a documented history of obesity or overweight and used a GLP-1 within the past 12 months. Your full history decides it, not a number alone.

No. Those are FDA-approved branded products. What is prescribed here may be a compounded semaglutide or tirzepatide prepared by an independent licensed pharmacy for you specifically. Compounded medications are not FDA-approved. Your clinician will talk through both routes with you.

You complete a clinical intake, then a licensed clinician reviews your health history and goals. Depending on your state you will either schedule a video visit or complete an asynchronous review. If a medication is appropriate, you start a subscription, create your patient portal password, and your prescription is sent to a partner pharmacy. Follow-up visits are typically monthly at first.

Options run from $249 to $339 per 4 weeks depending on the medication and route. One price covers clinician review, medication if prescribed, base labs where indicated, shipping and ongoing support. There is no separate membership fee and no consult fee. Charges may appear on your statement as “OPNLP PureMuze”.

No. Insurance does not cover the virtual visits in this program, and the subscription price is what you pay. If you have insurance that covers a branded GLP-1, your care team can help you pursue that route separately, including help with a prior authorization.

A GLP-1 is generally not appropriate if you are pregnant, breastfeeding or trying to conceive, or if you have end-stage kidney disease, severe liver disease, an active or past eating disorder, current suicidal thoughts or a prior attempt, active cancer treatment, a history of pancreatitis, an organ transplant on anti-rejection medication, a severe GI condition such as gastroparesis or IBD, or a personal or family history of medullary thyroid cancer or MEN2. A clinician screens for all of this during intake.

Yes, for most patients. The exception is a BMI under 22, which is better managed in person than virtually. To qualify you need a prior diagnosis of obesity (BMI over 30) or overweight (BMI over 27) and GLP-1 use within the past 12 months.

No. Your clinician reviews your history first and orders labs if they are needed, which may include a CMP, hemoglobin A1C, TSH and a lipid panel. If you have results from the last 24 months you may not need new ones. Upload them in the portal or email them to support@puremuze.com.

Your monthly subscription covers monthly clinician visits, weekly group coaching on nutrition, mindset and movement, 1:1 nutritionist support with chat access, care coaching from a Certified Medical Assistant every two weeks, comprehensive lab testing through Quest Diagnostics, and help navigating prior authorizations. These services are delivered by our clinical infrastructure partner, OpenLoop, and are included in the Medical Weight Loss program price.

It varies, and we will not promise a number. Most people titrate slowly over the first weeks so side effects stay manageable. Results are not guaranteed and vary by individual.

You must be at least 18 years old.

Your clinician reassesses whether continuing is clinically appropriate. Some patients still qualify for maintenance therapy depending on their history and symptoms, and some do not.

Labs completed at any Quest Diagnostics location are included in your subscription at no extra cost. You can also upload prior results or email them to support@puremuze.com. If you are not near a Quest, your clinician can write a general lab requisition, though running them at your primary care office is often cheaper. Costs vary if you use insurance or a different facility.

Yes. If you are pursuing an insurance-covered branded GLP-1, your care team helps navigate the prior authorization process with your plan.

Tell your clinician. Many women do better starting on our Microdosing program and moving up later, and your clinician can move you between programs as things change.

A licensed clinician on the PureMuze provider network, who can prescribe medication, order labs, review symptoms and build your plan. Our network composition is described in our Terms of Use.

Microdosing uses lower, subtherapeutic doses of compounded GLP-1 or GLP-1/GIP formulations, blended with other active ingredients such as B12 and MIC, L-carnitine or NAD+. The goal is day-to-day support for energy, metabolic balance and mental clarity rather than weight loss as the primary outcome.

Different goal, not just a smaller number. Standard dosing is built around weight as the primary outcome and titrates upward. Microdosing holds a low dose and pairs it with other actives to support energy, focus and metabolic function. Many women also find the lower dose easier on the stomach.

Medical Weight Loss treats weight as the outcome and uses standard titration. Microdosing pairs a low dose of the same molecules with B12 and MIC, L-carnitine or NAD+ to support energy, focus, muscle preservation and metabolic function. Your clinician can move you between the two as your goals change.

Either as a weekly injection or a daily oral tablet. Your clinician recommends the route and schedule that fits your goals and your history.

A compounded GLP-1 is a custom preparation made by an independent licensed pharmacy against a clinician's prescription for one specific patient. Compounded medications are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. See our Compounded Medication Disclosure.

Mild gastrointestinal symptoms such as nausea, constipation or reduced appetite, most often early on. They are frequently temporary and reported less at microdosing levels than at standard doses. Tell your clinician about anything that concerns you.

Emerging research is exploring GLP-1 effects on cardiovascular health, inflammation, cognition and liver function. That research is ongoing and unsettled, and compounded microdose formulations specifically have not been studied for those outcomes. We will not tell you otherwise.

You do not have to decide alone. Core blends lean toward metabolic support and muscle preservation. Energy & Mental Acuity adds NAD+ for cognitive clarity. Start any intake and your clinician recommends the formulation that fits your history.

Often yes, but your clinician needs the full picture. Some medications and conditions call for adjustments or extra monitoring, so disclose everything you take, including supplements.

It differs from person to person. Some people report support within a few weeks, others take longer, and some notice little. Consistency matters, and your goals are worth revisiting with your clinician as you go.

Balanced nutrition with adequate protein, resistance training, hydration, quality sleep and stress management. Medication is one input. These are the ones that compound.

Yes. Your clinician can move you between programs as your goals change. Some women start here for energy and focus and stay; others use it as a step toward Medical Weight Loss.

Menopause is the point at which menstrual periods have stopped permanently, diagnosed after 12 consecutive months without one. Perimenopause is the run-up, when cycles turn irregular and symptoms usually begin. Common symptoms include hot flashes, night sweats, vaginal dryness, painful intercourse, low libido, disrupted sleep, mood changes, brain fog, joint pain, fatigue, weight gain and bladder issues.

Systemic hormone therapy with estradiol, as a patch, gel or tablet, is generally used for hot flashes, night sweats, sleep and mood. Local vaginal estradiol is used for dryness, painful sex and recurrent UTIs. Micronized progesterone is required alongside systemic estrogen for anyone with a uterus. Non-hormonal options for hot flashes include paroxetine and desvenlafaxine. This program offers four of these routes.

Systemic HRT is generally offered to women under 60, or within 10 years of menopause, who have bothersome symptoms and no contraindications. Contraindications include a history of breast cancer, heart attack, stroke, blood clots or unexplained postmenopausal bleeding. Women aged 35 to 39, or 66 and older, are typically eligible for local vaginal therapy only.

Estrogen on its own thickens the uterine lining and raises the risk of endometrial cancer. Adding progesterone protects the lining and sharply reduces that risk. Women who have had a hysterectomy are not required to take progesterone alongside estradiol, though some choose to for symptom relief.

No. Perimenopause symptoms often begin years before periods stop. Your clinician will review where you are and what fits.

Vaginal estrogen often takes 2 to 6 weeks. Systemic estrogen and progesterone for hot flashes, sleep and mood usually take 4 to 8 weeks, sometimes sooner. Timelines vary and results are not guaranteed.

Paroxetine or desvenlafaxine, which some clinicians use for hot flashes when hormone therapy is not a fit. Both are prescription medications with their own trade-offs, and your clinician will walk you through them.

Contact your clinician immediately. Any vaginal bleeding after menopause is treated as abnormal until a clinician establishes otherwise. Do not wait for your next scheduled visit.

Yes. Age-appropriate cancer screening, including mammogram, Pap and HPV testing and colonoscopy, remains essential while you are on hormone therapy. This program does not replace primary care.

No. It is not appropriate for every history, which is exactly why a licensed clinician reviews your intake before anything is prescribed and why some people are declined.

Vaginal estrogen is generally continued long term, because genitourinary symptoms are progressive and do not resolve on their own. Systemic HRT is re-evaluated periodically with your clinician. Many women continue as long as the benefits outweigh the risks for them.

Sometimes. Low-dose vaginal estrogen is frequently prescribed for breast cancer survivors with severe genitourinary symptoms, but that decision is made case by case with your oncologist and your menopause clinician, not through an online form.

Contact your clinician right away. Most side effects can be managed by adjusting the dose or switching formulation, for example from a cream to a patch. Do not stop a hormone medication abruptly without guidance.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme derived from vitamin B3 that every living cell uses in energy metabolism and DNA repair. Levels tend to decline with age. That decline is why NAD+ is studied in the context of aging, though the research is still developing and outcomes are not guaranteed.

People typically use it seeking support for energy, mood and mental clarity, recovery and general healthy aging. Research in these areas is ongoing rather than settled. These are compounded products, are not FDA-approved, and we will not claim they reverse aging or treat any condition.

Most people report none. Some experience headache, flushing, nausea, diarrhea, dizziness, cramping, fatigue, or redness or bruising at the injection site. If you get sensitivity at a site, rotate to a different one. If symptoms persist, stop and contact your care team.

Sermorelin is a synthetic analogue of a naturally occurring hormone that signals the pituitary gland to release growth hormone. It is prescribed and compounded for an individual patient and is not FDA-approved.

It is used to support the body's own growth hormone signaling. Patients commonly report interest in energy, sleep quality, mood and recovery. Individual response varies widely, outcomes are not guaranteed, and your clinician will be direct with you about what it can and cannot do.

Most commonly, reactions at the injection site: irritation, itching, sensitivity, swelling, pain or redness. Less commonly: difficulty swallowing, dizziness, flushing, headache, nausea, rash, drowsiness, taste changes or restlessness. If side effects worsen, hold the medication and contact your clinician. If you develop swelling of the lips, tongue or face, or difficulty breathing, call 911 immediately.

B12-MIC is an injectable combining vitamin B12 with three lipotropic compounds: methionine, inositol and choline. It is the lowest-cost option in this program and is often used alongside a metabolic plan.

It may not be appropriate if you have liver or kidney disease, an allergy to cobalamin (B12) or any of the MIC components, or certain metabolic disorders. Anyone pregnant or breastfeeding should speak with a clinician before use.

No. These are prescription compounded medications dispensed by an independent licensed pharmacy after a clinician's review, not over-the-counter supplements.

It is typically used to support fat metabolism, energy levels and liver function as part of a broader plan. It is not a weight loss medication on its own.

Generally mild: redness or irritation at the injection site, mild digestive upset or increased urination. Allergic reactions are rare. Contact a clinician about anything unusual.

Often yes. Tell your clinician everything you are already taking and they will review whether adding support is appropriate for you.